Open access
Aug 2026
CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol
This study uncovers a CDK4/MERCs/PINK1 axis mediating PFOA/HFPO‐TA‐induced myocardial toxicity and identifies CAG as a promising natural product for mitigating environmental pollutant‐induced cardiac senescence, offering insights for PFAS health risk assessment and intervention strategies.
Nuo-Wa Li, Junze Jiang, Ying-Ying Liu et al.
· Advancement of science · 0 citations