Context-Dependent Roles of NCOA4-Mediated Ferritinophagy in Liver Diseases: From Ferroptosis to Fibrosis Reversal and Therapeutic Targeting
Nuclear receptor coactivator 4 (NCOA4) is the cargo receptor that mediates ferritinophagy, the selective autophagic degradation of ferritin, thereby controlling iron bioavailability. In the liver, this pathway is essential for iron homeostasis, but its dysregulation contributes to ferroptosis and multiple liver disease...