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Tian-Xing Zhou

2 papers indexed here

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Sep 2026

Chemotherapy Reawakens Dormant Disseminated Pancreatic Cancer Cells in the Liver by Promoting Senescent Hepatocyte-Induced Neutrophil Extracellular Traps.

Chemotherapy remains a cornerstone treatment for pancreatic ductal adenocarcinoma (PDAC), yet it paradoxically promotes metastatic recurrence. Elucidation of the underlying mechanisms mediating chemotherapy-induced metastasis could help identify improved combination treatment strategies. Here, we used a dormancy-tracki...

Shang-Heng Shi, Jing-Rui Yan, Yu Zhang et al. · 0 citations
Sep 2026

Abstract B024: Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring

It is demonstrated that senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring, revealing a closed link between cellular senescence and PDAC metastasis.

Tian-Xing Zhou · 0 citations

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