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Review Aug 2026

Targeting immunosuppressive tumor microenvironment to combat immunotherapy resistance: From mechanistic insights to therapeutic strategies.

With advances in deciphering the intricate interplay between tumors and the immune system, tumor immunotherapy has flourished significantly and has revolutionized conventional tumor therapies, owing to its durable immunological memory and favorable safety profile. Nevertheless, immunotherapy is not currently beneficial...

Pengfei Su, Ying-Jing Zhang, T. Yu et al. · 0 citations
Open access Jul 2026

FADS1-mediated Efferocytosis in Tumor-Associated Macrophages Shapes an Immunosuppressive Microenvironment in Gastric Cancer

This study highlights FADS1+TAMs as a critical component of GC progression and a potential exploratory biomarker for immunotherapy responsiveness, and pharmacological inhibition of FADS1 represents a promising combinatorial strategy for reshaping the TME and enhancing immune checkpoint blockade efficacy in preclinical...

Ying-Jing Zhang, Rong-Yuan Wei, Peng-Fei Su et al. · 0 citations

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