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Tian-Yu Kong

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Sep 2026

Saquinavir inhibits pyroptosis by regulating NLRP3 degradation to alleviate acute lung injury.

BACKGROUND In critically ill patients, sepsis can precipitate acute lung injury (ALI), a syndrome with high incidence in intensive care settings. Pyroptosis plays an important role in ALI, highlighting its potential as a drug target. The NLRP3-mediated classical pyroptosis pathway is notably implicated in this pathogen...

Tian-Yu Kong, Xiao-Yue He, Zi-Xian Yin et al. · 0 citations

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