Single-cell foundation models (scFMs) are transforming computational biology by enabling generalizable, task-agnostic representations for versatile single-cell analysis. Despite their progress in facilitating rapid deployment for downstream tasks, off-the-shelf scFMs still have some overlooked concerns: (I) (Pretrainin...
Tian-Yu Liu, Fan Zhang, Jia-Yuan Chen et al.· 0 citations
Rare-disease diagnosis is a long-tail reasoning problem: phenotypes are incomplete, individual disorders are sparsely documented, and relevant evidence is distributed across ontologies, gene annotations, and biomedical text. Language models consequently favor common conditions, miss rare candidates, or produce plausibl...
Bo Zhang, Yu-Chen Wang, Dong-Bai Li et al.· 0 citations
BackgroundAlzheimer's disease (AD), the most common age-related neurodegenerative disease, is closely associated with both amyloid-β plaque and neuroinflammation. Two thirds of AD patients are female, and they have a higher disease risk; women with AD have more extensive brain histological changes than men along with m...
Le Zhang, Tian-Yu Liu, Chuan He et al.· Journal of Alzheimer's Disea...· 0 citations
Cell-type-specific decomposition of genome-wide PRSs for CAD identified biologically distinct lipid interactions that were not captured by the genome-wide PRS, highlighting the potential of cell-type-informed PRSs to improve the biological interpretation of PRSs and provide insights into the heterogeneous mechanisms un...
Jia-Qi Hu, Le-Qi Xu, Tian-Yu Liu et al.· medRxiv· 0 citations
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