The role of TNF - α signaling pathway in rheumatoid arthritis and the therapeutic progress of TNF-α monoclonal antibodies
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and progressive joint destruction. Tumor necrosis factor - α (TNF - α) plays a central regulatory role in its inflammatory network. At present, biological agents such as TNF - α monoclonal antibodies (mAbs) have been widely used in cl...