Dendrimer Delivered shRNA Targeting the CCL20–CCR6 Axis Suppresses Complement-Mediated Microglial Synaptic Pruning and Ameliorates Chronic Neuroinflammation After Repetitive Traumatic Brain Injury
Repetitive traumatic brain injury (rTBI) induces persistent microglial activation and chronic neuroinflammation, yet the upstream signals driving long⍰term synaptic injury remain unclear. In this study, we identify the CCL20–CCR6 chemokine axis as a critical regulator of sustained microglial activation and complement⍰d...