Tie-Min Li

Metformin-loaded multi-enzymatic metal-organic framework nanozyme mediates metabolic reprogramming via multiple energy blockades to boost tumor immunotherapy.

Glycolytic metabolism of tumor cells suppresses the activity of immune cells, and multiple blocking energy supply and remodeling the metabolic microenvironment are important strategies to enhance immunotherapy. Using manganese-doped porphyrin metal-organic framework (MOF) as a carrier, by depositing ultrasmall Au nanop...