Epigenomics in severe male infertility: sperm-derived cell-free DNA methylation for prediction of sperm retrieval.
PURPOSE OF REVIEW Severe male factor infertility is increasingly managed with surgical sperm retrieval, yet current noninvasive predictors cannot reliably distinguish men with retrievable focal spermatogenesis from those with global spermatogenic failure. This review evaluates epigenomic approaches, with emphasis on se...