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Tim Rollenske

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Open access Aug 2026

Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota

The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages—both of which play critical roles in immune surveillance, barrier integrity, and tissue homeostasis. While their feta...

D. Obwegs, Alexander Oschwald, L. Koetter et al. · 0 citations
Open access Aug 2026

AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins

This work presents a scalable mammalian cell-display workflow to identify AI-designed minibinders against cancer surface targets and identifies biochemical optimization beyond the binding interface as a critical requirement for translating AI-minibinders into functional applications.

B. Broske, B. McEnroe, S. C. Frechen et al. · 1 citation

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