Timothy C. Meredith

Reconstitution of the LnsAB lipoprotein N-acylation system complex from Staphylococcus aureus and characterization of substrate preference

In Staphylococcus aureus, over 50 different types of lipoproteins are tethered to the membrane surface through acylation of an N-terminal cysteine residue where they perform multiple cellular roles, from nutrient transport to displaying virulence factors. Lipoproteins are also key focal points for detection by the toll...