Author

Timothy H. Tran

2 papers indexed here

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Open access Aug 2026

C-terminus CD28 phosphorylation, Y218, modulates IL-2 secretion and therapeutic effect of CAR-T cells.

CD28 is a co-stimulatory component of several second-generation chimeric antigen receptor (CAR)-T cells, providing signals essential for T cell proliferation, survival, and cytokine secretion. However, the specific contribution of individual CD28 intracellular motifs to CAR-T cell function remains incompletely understo...

Elena Martinez-Planes, M. C. Ramello, Miguel G. Fontela et al. · Molecular Therapy · 0 citations

Open access Aug 2026

Unc-51 like kinase 3 (ULK3) contributes to autophagy and cell survival in multiple myeloma

Despite effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. Analysis of RNA sequencing data from CD138 + MM patient cells (n = 813) across disease stages identifies an autophagy gene signature. Particularly elevated ULK3 expression is strongly associated wi...

Marilena Tauro, Tao Li, P. Sudalagunta et al. · Nature Communications · 0 citations