Aug 2026
Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRAD.
The ability to target oncogenic signals has transformed oncology. Targeted therapies typically inhibit oncogenic kinases and GTPases. Therapeutic augmentation of tumor-suppressive signaling could be a viable alternative but poses challenges. Specifically, designing compounds capable of stimulating kinase activity is mo...
Lin Song Kretschmer, Dominique C. Mitchell, Jin Liu et al.
· Cell Chemical Biology · 1 citation