Author

Timothy R. Billiar

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Open access Aug 2026

Metabolic-epigenetic rewiring of CCR5hi monocytes sustains long-term trained immunity against lethal sepsis

Findings identify a lactate-KAT2B-H3K18la epigenetic axis that orchestrates the long-term reprogramming of CCR5hi monocytes, highlighting CCR5hi monocytes as a promising therapeutic target for modulating innate immunity against lethal sepsis.

Lingqi Xu, Wenyan Hao, Yingyi Yang et al. · Science Advances · 0 citations