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Author

Timothy R. Hughes

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2 papers indexed here

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Open access Oct 2026

Development of a nanomedicine approach to improve the therapeutic index of bexarotene

Bexarotene (BEX), a retinoid X receptor (RXR) agonist, has demonstrated therapeutic potential in oncology, neurodegenerative diseases and inflammatory conditions, including multiple sclerosis (MS). However, its broader clinical application is limited by poor aqueous solubility, low bioavailability, and dose-limiting ad...

Siân Rizzo, Carola Pepe, Thibault Albert et al. · 0 citations
Open access Apr 2025

Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice

Using transgenic 3xTg-AD mice, systemic infection with the β-herpesvirus murine cytomegalovirus (MCMV) accelerates the development of cognitive decline, tauopathy, and synaptic loss in the hippocampus, all of which are key features of AD.

M. Marsden, J. E. McLaren, Ryan J. Bevan et al. · 3 citations

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