Open access
Sep 2026
SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction
ABSTRACT Sepsis‐associated encephalopathy (SAE) is a severe neurological complication of sepsis, yet how metabolic disturbances engage epigenetic regulation in SAE remains unclear. We found that septic mice exhibited hippocampal succinate and succinyl‐CoA accumulation, accompanied by enhanced neuronal histone H2BK120 s...
Na Meng, Jia-Teng Zhou, Xiaoyu Guo et al.
· Advancement of science · 0 citations