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Ting-Jian Chen

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Open access Aug 2026

Engineered polymerase-mediated efficient synthesis of site-specifically functionalized RNA and 2’-modified RNA oligonucleotides via genetic alphabet expansion

2’-Modified RNA oligonucleotides have found broad use in biotechnology and biomedicine, requiring their efficient synthesis and controllable labelling. While engineered polymerases enable their synthesis, controllable labelling methods remain underdeveloped. Unnatural base pairs (UBPs) have been developed to expand the...

Jing Wu, Jun-Yan Mei, Zhi-Peng Chen et al. · 0 citations

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