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Author

Ting Liu

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Aug 2026

sAPPα acts as an endogenous ligand for TREM2 to regulate microglial survival and inflammatory responses in Alzheimer's disease.

BACKGROUND Triggering receptor expressed on myeloid cells 2 (TREM2) regulates microglial functions in Alzheimer's disease, whereas soluble amyloid precursor protein alpha (sAPPα) has neuroprotective effects. Whether sAPPα directly interacts with TREM2 remains unclear. METHODS Single-cell RNA sequencing data from wild...

Zong-Qin Wang, Mihail Liu, Jing Xu et al. · 0 citations

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