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Review Open access Sep 2026

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

ABSTRACT Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single‐cell, multi‐omics, and translational studies show that aged muscle is shaped by coordinated changes in myofibers, stem and stroma...

Ting Liu, Yao-Min Hu · 0 citations

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