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Review Open access Jul 2026

Prevention and Treatment of Staphylococcus aureus Biofilms Using Promising Agr-QS-Targeting Anti-Biofilm Agents

Staphylococcus aureus (S. aureus), a leading cause of nosocomial infections, contributes significantly to increased morbidity and mortality, especially when it forms biofilms on medical devices. This pathogen, specifically methicillin-resistant S. aureus (MRSA), remains a challenge to treat due to its ability to form b...

Salma Waheed Sheikh, Ahmad Ali, A. Ahsan et al. · 0 citations
Open access Aug 2026

ArlR regulates environmental stress tolerance and biofilm formation in foodborne Staphylococcusaureus

Staphylococcus aureus (S. aureus) is a major Gram-positive pathogen capable of sensing and responding to diverse host- and environment-derived stresses, contributing to both clinical infections and foodborne illnesses. This exceptional stress tolerance is primarily mediated by intricate regulatory networks. Although th...

Kai Ma, Bing-Tao Zhang, Xia-Yan Zhang et al. · 0 citations
Open access Jul 2026

The alternative sigma factor SigH modulates biofilm formation and stress tolerance in a raw milk-derived Staphylococcus aureus.

Staphylococcus aureus is an important raw milk contaminant that can persist in dairy environments through biofilm formation and adaptation to environmental stresses. Although the alternative sigma factor SigH has been described in S. aureus, its role in raw milk-associated strains remains poorly understood. In this stu...

Chao Li, Fanwenqing Kong, Wenting Li et al. · 0 citations
Open access Jul 2026

The cyclic adenosine monophosphate-ArcRsa signaling axis modulates biofilm formation in dairy-derived Staphylococcus aureus via transcriptional repression of ica operon.

Staphylococcus aureus has significantly contributed to the contamination of dairy products and preserved foods, attributed to its ability to colonize a wide range of environments and form biofilms. ArcR, the Crp/Fnr family regulatory protein in S. aureus plays key roles in various biological processes. However, the mol...

Haoyang He, Fanwenqing Kong, Xiaojia Xuan et al. · 0 citations

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