Author

Ting-Yuan Liu

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Open access Sep 2026

Decomposing population differences in type 2 diabetes through a high-resolution GWAS of ~600,000 individuals with East Asian ancestry

Type 2 diabetes (T2D) is a highly heterogeneous metabolic trait, with a higher prevalence in East Asians. Despite extensive genetic studies focusing mainly on Europeans, how genetic risk for T2D is distributed across biological pathways in East Asians in comparison with Europeans remains incompletely understood. Here,...

Kohei Saito, Hsing-Fang Lu, Tatsuhide Inoue et al. · Communications Biology · 0 citations

Open access Jul 2026

Genome-wide association and polygenic risk score analyses of MASLD-related hepatic steatosis severity in a Taiwanese Han population.

BACKGROUND Hepatic steatosis is a highly prevalent metabolic condition and a major contributor to chronic liver disease, particularly in Asian populations. This study was conducted to identify genetic variants associated with the severity of ultrasound-defined hepatic steatosis in a Taiwanese Han population and evaluat...

Ting-Yuan Liu, Jai-Sing Yang, Yu-Chia Chen et al. · Cell & Bioscience · 0 citations

Open access Aug 2026

Evaluation of population-specific polygenic risk scores for blood lipids: insights from Taiwanese cohorts and multiancestry meta-analysis

Background Blood lipids are heritable risk factors for cardiovascular disease (CVD), a leading cause of mortality worldwide. However, the genetic architecture of lipid traits and the performance of polygenic risk scores (PRSs) remain underexplored in East Asian (EAS) populations, including Taiwanese Han individuals. Me...

Yu-Chia Chen, Ting-Yuan Liu, Chi-Chou Liao et al. · Frontiers in Bioinformatics · 0 citations