Open access
Sep 2026
A novel Keap1-Nrf2 inhibitor 6K delays the progression of AKI-to-CKD by mitigating maladaptive repair
It is demonstrated that Nrf2 deficiency exacerbates AKI-CKD progression through redox imbalance and ferroptosis-mediated maladaptive repair, and targeting Keap1-Nrf2 with 6K protects against renal injury and fibrosis, highlighting its therapeutic potential for kidney diseases.
Yi-Ming Wang, Yi Sun, Ting Zhou et al.
· Redox Biology · 0 citations