GPR65 in cancer: expression heterogeneity, invasion and metastasis, the tumor immune microenvironment, and translational implications.
This review summarizes current evidence on GPR65 in cancer from an immunopharmacological perspective, and discusses its molecular characteristics and proton-induced Gs-cAMP-PKA signaling, then examines tumor cell-intrinsic and immune-mediated functions, including acid-adaptive survival, macrophage polarization, CD8+ T-...