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Author

Tobias Madl

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Open access Sep 2026

Structural insights into human caspase-9 CARD assembly modes driven by conserved arginine hotspots

Caspase-9 (C9) is a key initiator of the intrinsic apoptotic pathway and contains an N-terminal caspase activation and recruitment domain (CARD) that mediates homotypic and heterotypic interactions. While previous studies have shown that C9CARD can form filamentous assemblies under specific conditions, its intrinsic st...

Swasti Rawal, Christoph Grininger, Sem J. Peijnenborgh et al. · 0 citations

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