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Author

Tobias Stauber

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Open access Sep 2026

Lysosomal proteome and lipidome analyses of intestinal cells reveal the crucial role of bis(monoacylglycero)phosphate for autophagosome-lysosome fusion

The transport of about 70 enzymes to lysosomes depends on mannose 6-phosphate signals formed by GNPTAB. Editing of Gnptab in an intestinal mouse cell line revealed the loss of multiple lysosomal enzymes associated with the accumulation of sphingomyelins, ceramides, and cholesterol, and reduced levels of bis(monoacylgly...

Gianmarco Del Gallo, Zi-Lei Chen, Anne Sanner et al. · 0 citations
Open access Sep 2026

The intracellular subdomain of the volume-regulated anion channel subunit LRRC8A is a hotspot of channel activation

Volume-regulated anion channels (VRACs), formed by heteromers of LRRC8 subunits, mediate the transport of anions and organic osmolytes in numerous physiological processes. Although their gating mechanism remains poorly understood, conformational rearrangements of the cytosolic leucine-rich repeat domains (LRRDs) have b...

Sara Bertelli, Lu Wang, Malte Klüssendorf et al. · 2 citations

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