Author

Tobias Warnecke

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Open access Sep 2026

Single-residue variation in the nucleosome core reveals a regulatory hub for phenotypic innovation

The six-residue loop 2 of H2A and H2A is used to map, at single-residue resolution, how nucleosome-core variation reshapes cellular function, and identifies histone variation as a source of phenotypic innovation.

Zachary H. Harvey, Benjamin Gundinger, Jian-Yi Kok et al. · bioRxiv · 0 citations

Open access Aug 2026

Chromatin is dispensable for bacterial life

The successful construction of ΔNAP9 demonstrates that bacterial cells can carry out basic cellular functions in the absence of co-evolved chromatin proteins, highlighting the potential for radical (re-)engineering of prokaryotic chromatin and systems of gene expression.

Paul Villain, A. Hocher, Jacques Serizay et al. · bioRxiv · 1 citation