Author

Todd E. Golde

2 papers indexed here

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Review Open access Aug 2026

The tumor microenvironment of medulloblastoma: from emerging biological insights to novel therapeutic targeting

Medulloblastoma is the most common pediatric malignancy of the brain and spine and a major cause of childhood cancer-related morbidity and mortality. Novel therapeutic approaches are urgently needed. The malignant behavior of this disease is influenced both by cell intrinsic factors and by the complex interactions of t...

F. Chien, Marina E. Michaud, Martha E. Stewart et al. · Frontiers in Oncology · 0 citations

Open access Aug 2026

Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis

Background Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are components of the amyloid deposits in Alzheimer’s disease (AD) and other amyloidoses. HS and HSPGs are canonically thought to facilitate amyloid deposition by accelerating the aggregation of amyloidogenic proteins and impairing their clearanc...

K. Shim, Yong Ran, Danny Ryu et al. · bioRxiv · 0 citations