Author

Todd R. Golub

2 papers indexed here

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Aug 2025

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actionable fusions, the proto-oncogene is the drug target, the contributions to oncogenicity of the fusion partner have large...

Anna Borgenvik, Sean A. Misek, Daniel Christen et al. · bioRxiv · 1 citation

Open access Aug 2026

Dynamic inositol pyrophosphate synthesis is a targetable therapeutic opportunity in ovarian cancer

We previously reported that the phosphate exporter XPR1 is required to prevent toxic phosphate accumulation in ovarian cancer cells. To guide therapeutic development, we sought to systematically compare potential strategies to inhibit XPR1: directly targeting the phosphate efflux channel, targeting its partner protein...

Daniel P. Bondeson, David Husselbee, Saoirse Hanbury et al. · bioRxiv · 0 citations