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Author

Tom N. Grossmann

2 papers indexed here

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Review Open access Oct 2026

Chemical reactions for the ligand-directed modification of native proteins

Selective modifications of native proteins provide powerful opportunities to study and manipulate biological systems, yet achieving site-selective functionalization remains challenging due to the surfeit of competing amino acids, often addressed by genetic engineering of target proteins. Ligand-directed protein modific...

A. Haim, Cassandra J. Henderson, M. Akdeniz et al. · 0 citations
Open access Sep 2026

Remote Residue Substitution and Macrocyclization Preorganize a β‐Hairpin Peptide and Enhance β‐Catenin Binding

Peptide‐based inhibitors are promising tools to target challenging protein interfaces, yet improving their affinity and drug‐like properties is still a major hurdle. This holds particularly true for β‐sheet motifs with only limited strategies available to robustly stabilize their conformation. Previously, we reported l...

Michael H. N. Meulendijks, Yun Li, Frederik J. Steiner et al. · 0 citations

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