Author

Tom S. Smith

2 papers indexed here

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Open access Aug 2026

Choreographed morphogenetic events underlie early foregut development in the mouse embryo

Between embryonic days 7.5 and 8.5, the mouse embryo undergoes a dramatic rearrangement of its entire anterior, a process known as ventral folding: the near-simultaneous morphogenesis of the cardiac crescent, cranial headfolds, and anterior foregut that together establish the antero-ventral body plan. While cardiac mor...

J. Kretzschmar, Guillermo Serrano-Nájera, Sonia Agüera-González et al. · bioRxiv · 1 citation

Open access Oct 2026

The mTOR pathway drives daily physiology

How molecular clocks drive daily rhythms in mammalian physiology remains poorly understood. Here we show that the mechanistic target of rapamycin (mTOR) pathway is required for most daily variation in cellular and organismal physiology. PERIOD2 binds to mTORC1 and limits its activity, providing a route by which the clo...

Aiwei Zeng, A. Mihut, M. Anandapadamanaban et al. · bioRxiv · 0 citations