Inducing antigen-specific immune tolerance is a long-standing aim in organ-specific autoimmune diseases including multiple sclerosis (MS). We developed a therapy based on autologous red blood cells (RBCs) as tolerizing carriers of autoantigens and tested these in an open-label, dose-escalation, phase Ib clinical trial...
Andreas Lutterotti, Thomas Ludersdorfer, M. Docampo et al.· Proceedings of the National...· 1 citation
MS-associated methylation changes enriched in the cohesin chromatin-regulation pathway localised to T-cell regulatory regions included multiple protocadherin (PCDH) genes, which displayed consistent methylation and expression changes in CSF cells of pwMS compared to controls.
Ya-Nan Han, G. Zheleznyakova, Heng Liang et al.· EBioMedicine· 0 citations
Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.
Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al.· Nature Genetics· 0 citations
MLC1 antibodies identify a subset of patients with an NMOSD-like phenotype, underscoring their potential as a disease marker with pathogenic relevance.
H. Wong, Samantha Ho, Qian Yu et al.· Science Translational Medici...· 0 citations
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