Author

Tommy Alain

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Open access Sep 2026

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Findings show that multiple resistance-associated programs spanning signaling, cell survival, and metabolism share a dependency on eIF4A-dependent translation and provide a preclinical rationale to test whether adding eIF4A inhibition can prolong responses to MAPK-targeted therapy in melanoma.

Alejandro Schcolnik-Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad et al. · bioRxiv · 0 citations

Open access Jul 2026

Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women

RYGB improves systemic metabolic health and induces sustained skeletal muscle bioenergetic reprogramming characterised by enhanced expression of genes involved in myogenesis and protein translation, but decreased expression of genes involved in mitochondrial metabolism, which may reflect improved mitochondrial quality...

Chantal A. Pileggi, Dhanuddara Mohottalage, Luke S. Kennedy et al. · EBioMedicine · 0 citations