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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Tomoji Mashimo

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3 papers indexed here

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Open access Oct 2026

Persistent SARS-CoV-2 infection in SCID rats reflects immune vulnerability of the upper airway and trachea

ABSTRACT In immunocompromised patients, persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries the risk of prolonged viral shedding and emergence of new variants. To reproduce the key features of persistent SARS-CoV-2 infection and evaluate its transmissibility, mouse-passaged SARS-Co...

Kaya Miyazaki, Nozomi Shiwa-Sudo, N. Iwata-Yoshikawa et al. · 0 citations
Open access Sep 2026

Enhanced CRISPR-Cas3-mediated genome editing using circularized crRNAs

Summary Type I-E CRISPR-Cas3 represents a genome-editing technology in which large deletions averaging several kilobases are introduced in target regions. However, its genome-editing efficiency varies considerably across targets and cell types, making it difficult to achieve consistent results. Here, we investigated th...

Kouya Mikamo, K. Yoshimi, Naoko Abe et al. · 0 citations
Open access Aug 2026

A rapidly deployable CRISPR–Cas3 diagnostic platform for emerging RNA viruses

Rapidly converting viral genome information into deployable molecular tests remains a major challenge in outbreak preparedness. We developed CONAN-SWIFT (Simple Workflow for Isothermal Field Testing), a sequence-to-test platform that integrates computational assay design, reverse-transcription loop-mediated isothermal...

Jun Nakamura, Kaya Miyazaki-Iida, Shotaro Torii et al. · 0 citations

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