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Author

Tomoko Saito-Fujita

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Open access Oct 2026

Contribution of Topoisomerase IIα chromatin-tether and C-terminal domain to mitotic chromosome association and structural organization.

Mitotic functions of Topoisomerase IIα (TopoIIα) are dictated by its C-terminal domain (CTD), which is distinct from TopoIIβ. The chromatin-tether domain (ChT) within the αCTD recognizes methylated chromatin, an ability lacking for TopoIIβ and loss of αChT leads to ultrafine DNA bridges (UFBs) and chromosome bridges in...

B. Lama, Sanjana Sundararajan, A. Saraf et al. · 0 citations

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