Open access
Aug 2026
Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α‑Synuclein Phase Separation
It is revealed that NTD–CTD electrostatic crosstalk acts as the key modulator of α-synuclein phase separation, while NAC–NAC interactions play an auxiliary role, both of which synergistically govern α-synuclein phase separation.
Zhong-Yuan Yang, Yi-Ming Tang, Jitao Wen et al.
· JACS Au · 0 citations