The case for FP priming as a powerful method for engaging a vulnerable HIV Env epitope is strengthened, demonstrating that the TTT platform may serve as an effective boost to epitopes beyond FP, and how trimer architecture and dosing influence the trajectory of epitope targeting is clarified.
Shreyanshu Ray, Cheng Cheng, K. McKee et al.· Journal of Immunology· 0 citations
Hundreds of recall and de novo neutralizing monoclonal antibodies are isolated and characterized after sequential exposures to SARS-CoV-2 variants in ancestral-imprinted humans to reveal the distinct contributions of recall and de novo antibodies to a balanced immune response and underscore the benefit of updated boost...
T. Johnston, Shuk-Hang Li, M. Painter et al.· Nature Immunology· 2 citations
Assembly of flaviviruses such as Zika virus (ZIKV), dengue virus, and West Nile virus in the host cell endoplasmic reticulum is driven by the structural envelope (E) and premembrane (prM) proteins. The formation of an infectious virion requires cleavage of prM by the host furin protease during a maturation step that is...
Kimberly A. Dowd, Michelle Schroeder, Egan Sanchez et al.· Science Translational Medici...· 0 citations
The dependence of effective variant-specific antibodies on vaccination history is shown which may explain birth-year influence on differential susceptibility to SARS-CoV-2 variants XFG and BA.3.3.2, and it is suggested that vaccination regimens in children should prioritize neutralization breadth.
T. Johnston, Rahul Subramanian, Wakinyan Benhamou et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
