Tong Sha

Spatial organization of the TNBC tumor microenvironment: multicellular niches, T-cell bottlenecks, and therapeutic opportunities.

How myeloid programs and neutrophil extracellular trap formation, cancer-associated fibroblast subsets and extracellular matrix barriers, aberrant vasculature and hypoxia-linked metabolism, and the tumor-nerve signaling axis cooperatively shape immunosuppressive niches that drive progression and therapeutic resistance is delineated.