Author

Tong-Xin Shang

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Review Open access Aug 2026

Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design

Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...

Yutong Wei, Jie Wang, Ya-Nan Ji et al. · Drug Design, Development and... · 0 citations

Review Open access Sep 2026

Role of the cGAS-STING signaling pathway in diabetes mellitus and its complications: from mechanisms to therapeutics

A novel perspective on the inflammatory mechanisms underlying diabetes mellitus and its complications is provided, thereby establishing a theoretical foundation for the development of therapeutic strategies centered on modulating the cGAS-STING pathway.

Guang-Dong Qi, Tong-Xin Shang, Hua-Lin Sun et al. · Frontiers in Pharmacology · 0 citations

Review Aug 2026

The role and mechanisms of the cGAS-STING signaling pathway in age-related pathophysiological processes: challenges and therapeutic strategies.

The mechanisms of cGAS-STING activation in aging-including mitochondrial DNA leakage, nuclear envelope disruption, and retrotransposon activation-and its role in driving cellular senescence and the senescence-associated secretory phenotype (SASP) are reviewed.

Yutong Wei, Sutong Cai, Ya-Nan Ji et al. · Biochemical Pharmacology · 4 citations