Author

Tongyu Xu

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Preprint Aug 2026

Is Retrieval All You Need? Assessment and Emergence of Novelty in Protein Structure Generation

RetFold is proposed, a zero-training baseline that constructs backbones by retrieving CATH domains and refining inter-domain connections through geometry-based helix-linker optimization, at two orders of magnitude lower cost on CPU alone.

Tongyu Xu, Yijie Zhang, Mutian He et al. · 0 citations