Protodioscin alleviates cyclophosphamide-mediated liver damage in mice by targeting Nrf2/HO-1, NF-κB/NLRP3 inflammasome, and mitochondrial apoptosis pathways.
Cyclophosphamide is a currently used antineoplastic drug to manage a number of malignant tumors. Hepatotoxicity is one of the most significant complications of cyclophosphamide therapy, which restricts its clinical application. Protodioscin, as a natural saponin, possesses multiple striking biological properties. This...