Subthreshold early white-matter hyperintensity increase predicts accelerated hippocampal and whole-brain atrophy in anti-amyloid-β immunotherapy
A transient WMH surge within the first 60 days of therapy mirrors the known time course of amyloid-related imaging abnormalities and independently predicts accelerated long-term hippocampal and whole-brain atrophy, highlighting its potential as an early prognostic imaging marker.