Author

Trevor A. Graham

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Open access Sep 2026

IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial

Successful cancer immunotherapy requires not only tumor cell killing but also the activation of innate and adaptive immune responses. The inhibitor of apoptosis (IAP) proteins cIAP1, cIAP2 and XIAP act as key suppressors of RIPK1-driven immunogenic cell death, thereby enabling tumor immune evasion and limiting the ef...

C. Tiu, Wing Yau, T. Tenev et al. · Nature Communications · 0 citations

Open access Oct 2026

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

It is shown that the neoplastic evolution of mismatch repair deficient (MMRd) clones leads to large-scale and sustained reorganisation of the T-cell repertoire in colon and peripheral blood, which defines the local and circulating TCR landscape associated with colonic neoplasia in Lynch syndrome and provides a framewor...

Penelope V. Edwards, O. Swinyard, T. Ronel et al. · bioRxiv · 0 citations

Open access Aug 2026

Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilities

Epigenetics is central to tumorigenesis, but the co-evolution of the cancer epigenome and its microenvironment is severely understudied. Here, we measure chromatin accessibility and transcriptome, at single cell resolution, of a set of normal colon, primary colorectal cancers and metastases, and identify recurrent epig...

Alexandra Livanova, Luca Azzolin, F. Cambuli et al. · bioRxiv · 0 citations

Review Sep 2026

A guide to understanding tumour evolution through the lens of population genetics.

It is argued that population genetics provides the mathematical framework needed to extract evolutionary dynamics from cancer genomes and it is shown how models of mutation, selection and drift transform allele frequencies from descriptive measurements into quantitative estimates of clonal fitness and evolutionary timi...

G. Caravagna, Trevor A. Graham, A. Sottoriva · Nature Reviews. Cancer · 1 citation

Open access Jul 2026

Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples

An open-source Bayesian inference tool that determines the multiplicity and copy number of driver mutations from tumor sequencing datasets is presented, an open-source Bayesian inference tool that determines the multiplicity and copy number of driver mutations from tumor sequencing datasets.

N. Calonaci, E. Krasniqi, D. Čolić et al. · Nature Genetics · 0 citations