Open access
Sep 2026
AI-guided epitope engineering of a SARS-CoV-2 spike antigen for broad sarbecovirus neutralization
The rapid evolution of SARS-CoV-2 and the ongoing risk of zoonotic spillover highlight the need for vaccines that provide broad protection beyond strain-specific immunity. Here, we present a structure-guided, AI-enabled strategy for rational antigen design that enhances cross-reactive B-cell epitope recognition across...
A. Odainic, Ioannis Vardaxis, M. Ferraz et al.
· Frontiers in Immunology · 0 citations