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Tri Cao Vu

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Open access Oct 2026

Structure-Guided Optimization of a LipL32-Targeting DNA Aptamer through Molecular Dynamics and Free-Energy Analysis

Accurate detection of leptospirosis requires high-affinity recognition of the conserved LipL32 biomarker. Although LipL32-targeting DNA aptamers have been identified through systematic evolution of ligands by exponential enrichment (SELEX), the molecular basis of their target recognition remains unclear, limiting rat...

Tri Cao Vu, Boonchoy Soontornworajit, Pichayanoot Rotkrua et al. · 0 citations

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