Tsegaw Bahlibi

Mechano-activated synovial cells instigate OA-like disease progression in the absence of joint injury

While altered tissue mechanics and cellular mechanoactivation accompany osteoarthritis, whether dysregulated mechanotransduction can initiate joint disease remains unclear. Here, we used intra-articular delivery of cell-penetrating TAT-Cre recombinase to locally perturb the actomyosin–Hippo mechanotransduction axis in...