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Author

T.T. Xu

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Open access Aug 2026

The integrated stress response kinase GCN2 prevents ZAKα-Dependent inflammatory hyperactivation in macrophages.

Translational control is redefined as a central checkpoint in macrophage activation, revealing how GCN2 mitigates ribosomal stress to prevent inflammatory hyperactivation, with potential therapeutic implications for TNFα-driven inflammatory diseases.

R. D. Requião, L. F. Lima-Silva, P. Estevão et al. · 0 citations