Polyphenol-crosslinked green synthesis of mucoadhesive chitosan nanoparticle encapsulated with cisplatin for localized management of cervical cancer.
Chitosan (CS) nanoparticles have been widely investigated for cervical cancer (CC) therapy, with tripolyphosphate (TPP) commonly used as a crosslinker. This study explored ellagic acid (EA), a natural polyphenol with anticancer activity, as an alternative crosslinker for cisplatin-loaded EA-crosslinked CS nanoparticles...