Open access
Sep 2026
Process Analytical Technology (PAT) for Continuous Purification of mRNA via Precipitation and Tangential Flow Filtration.
Continuous downstream processing of messenger ribonucleic acid (mRNA) therapeutics requires purification strategies that are scalable, robust, and capable of removing product- and process-related impurities from in vitro transcription mixtures. Precipitation-based purification coupled with tangential flow filtration (T...
Rajan R. Bhawnani, Maria del Carme Pons Royo, Rohan P. Kadambi et al.
· Biotechnology and Bioenginee... · 0 citations