Author

Tyler Myers

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Conference Open access Aug 2026

Prediction and Entropy of Evolving Sequences: A Transformer-Based Estimator of Functional Information

To resist thermodynamic disorder, living systems maintain low entropy genomic configurations through selection. We propose pseudo-perplexity, the per position surprisal of a masked language model, as an estimator of this biological functional information. Using a unified framework, we demonstrate that transformer deriv...

Tyler D. Myers, Se-Jin Song, A. Bartko · IEEE Symposium on Artificial... · 0 citations

Open access Aug 2026

Spatial transcriptomics reveals site-specific cellular and metabolic heterogeneity in bladder carcinoma in situ

Bladder carcinoma in situ (CIS) is a multifocal, non–muscle-invasive disease with a high risk of progression to muscle-invasive cancer. Current management strategies are often guided by genomic profiling of single tumor samples, which incompletely capture tumor heterogeneity and may contribute to treatment failure. In...

Tyler D. Myers, A. Salmasi, M. Meagher et al. · bioRxiv · 0 citations